• AEBSF.HCl: Unraveling Protease Inhibition in Necroptosis ...

  2025-10-22

  Explore how AEBSF.HCl, a leading irreversible serine protease inhibitor, enables transformative research into necroptosis, amyloid-beta production, and protease-driven cell signaling. This article offers a unique systems-level perspective, integrating recent mechanistic findings with advanced experimental strategies.

• Reimagining Amyloid-β Pathway Modulation: Strategic Guida...

  2025-10-21

  This thought-leadership article explores the mechanistic underpinnings, experimental validation, and translational strategy for BACE1 inhibition in Alzheimer’s disease research. Focusing on Lanabecestat (AZD3293)—a blood-brain barrier-penetrant, orally active BACE1 inhibitor—the piece synthesizes recent evidence, such as the synaptic-sparing effects of moderate β-secretase inhibition, and positions Lanabecestat as an enabling tool for next-generation neurodegenerative disease models. The narrative escalates beyond standard product information by offering strategic, evidence-based guidance for translational research teams.

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